[Study on supercritical carbon dioxide fluid extraction process of lignans from Kadsura heteroclita (Roxb.) Craib].

OBJECTIVE

To optimize supercritical carbon dioxide fluid extraction process parameters of lignans from Kadsura heteroclita (Roxb.) Craib.

METHODS

The supercritical carbon dioxide fluid extraction was adopted to extract lignans. The contents of total lignans and gamma-schisandrin were determined to test the influence of pressure, temperature, grinding particle size and flow rate of CO2.

RESULTS

The extraction pressure and grinding particle size had significant effects on the content of total lignans and gamma-schisandrin. However, The extraction temperature and flow rate of CO2 had no significant effect on them.

CONCLUSION

The optimum process parameters are as fouons: pressure is 10 MPa, temperature is 45 degrees C, flow rate of CO2 is 30 L/h and herbs are granulated.