Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2026
Investigation of the Pattern of Changes in Hepatic Artery Resistive in Patients Undergoing Deceased Donor Liver Transplantation.
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Aliakbarian Mohsen, Hoseinzadeh Fahimeh, Salari Maryam, Khodashahi Rozita, Ahmadzadeh Amir Mahmoud
Аннотация
OBJECTIVES: Postoperative hepatic artery resistive index is strongly influenced by perioperative hemodynamics and graft-related factors. However, evidence linking prognostic variables to early postoperative hepatic artery resistive index remains limited and hete-rogeneous. This study explored changes in hepatic artery resistive index and whether changes were associated with patient-level exposures and prog-nostic variables.
MATERIALS AND METHODS: We analyzed retrospective data from 323 patients who underwent deceased donor liver transplant at the Montaserieh Transplant Center Registry of Mashhad University of Medical Sciences between 2014 and 2021. Patient demographic charac-teristics and clinical assessments were analyzed. Doppler sonographies performed before and during the first 3 days posttransplant were used to measure hepatic artery resistive index. We used SPSS version 27 and R-Studio version 4.5.1 for analyses.
RESULTS: Mean age of patients was 48.71 ± 1.022 years. Mean hepatic artery resistive index increased among patients aged ≤50 years from day 0 (0.762 ± 0.149) to day 1 (0.789 ± 0.141), showed continuous upward trend in patients aged >50 years, increasing from day 0 (0.778 ± 0.136) to day 3 (0.835 ± 0.105), and was significantly higher in patients aged >50 years on day 2 (0.031; P = .012) and day 3 (0.044; P < .001) compared with patients aged ≤50 years. Older deceased donor age was associated with increased mean hepatic artery resistive index over time (0.083, P = .029). Although baseline resistive index and liver injury markers were significantly associated with subsequent changes in hepatic artery resistive index, no significant association was observed for Model for End-Stage Liver Disease score.
CONCLUSIONS: With an association shown between age and higher hepatic artery resistive index, trend analysis may help identify high-risk groups for arterial thrombosis. Further research is needed to better clarify the relationships between Model for End-Stage Liver Disease scores and clinical outcomes.
MATERIALS AND METHODS: We analyzed retrospective data from 323 patients who underwent deceased donor liver transplant at the Montaserieh Transplant Center Registry of Mashhad University of Medical Sciences between 2014 and 2021. Patient demographic charac-teristics and clinical assessments were analyzed. Doppler sonographies performed before and during the first 3 days posttransplant were used to measure hepatic artery resistive index. We used SPSS version 27 and R-Studio version 4.5.1 for analyses.
RESULTS: Mean age of patients was 48.71 ± 1.022 years. Mean hepatic artery resistive index increased among patients aged ≤50 years from day 0 (0.762 ± 0.149) to day 1 (0.789 ± 0.141), showed continuous upward trend in patients aged >50 years, increasing from day 0 (0.778 ± 0.136) to day 3 (0.835 ± 0.105), and was significantly higher in patients aged >50 years on day 2 (0.031; P = .012) and day 3 (0.044; P < .001) compared with patients aged ≤50 years. Older deceased donor age was associated with increased mean hepatic artery resistive index over time (0.083, P = .029). Although baseline resistive index and liver injury markers were significantly associated with subsequent changes in hepatic artery resistive index, no significant association was observed for Model for End-Stage Liver Disease score.
CONCLUSIONS: With an association shown between age and higher hepatic artery resistive index, trend analysis may help identify high-risk groups for arterial thrombosis. Further research is needed to better clarify the relationships between Model for End-Stage Liver Disease scores and clinical outcomes.