Journal of perinatology : official journal of the California Perinatal Association · 2020
The effect of prolonged tracheal intubation on the association between patent ductus arteriosus and bronchopulmonary dysplasia (grades 2 and 3).
СтатьяНаблюдательное исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Clyman Ronald I, Hills Nancy K
Аннотация
OBJECTIVE: To determine if the need for mechanical ventilation alters the association between prolonged patent ductus arteriosus (PDA) exposure and bronchopulmonary dysplasia (grades 2 and 3) (BPD).
STUDY DESIGN: Observational study of 407 infants (<28 weeks' gestation) with echocardiograms performed at planned intervals.
RESULTS: Twelve percent (48/407) of study infants had BPD (grades 2 and 3). In a multivariable regression model, exposure to a moderate-to-large PDA shunt for ≥7 days was associated with an increased risk of BPD (grades 2 and 3) (from 16 to 35%: aRD = 19% (6, 32%), p < 0.005) when infants required ≥10 days of intubation (n = 170). In contrast, there was no significant association between prolonged PDA exposure and BPD when infants required ≤9 days of intubation (aRD = 4%) (-1, 10%) (n = 237).
CONCLUSIONS: Moderate-to-large PDAs are associated with an increased risk of BPD-but only when infants require intubation ≥10 days.
STUDY DESIGN: Observational study of 407 infants (<28 weeks' gestation) with echocardiograms performed at planned intervals.
RESULTS: Twelve percent (48/407) of study infants had BPD (grades 2 and 3). In a multivariable regression model, exposure to a moderate-to-large PDA shunt for ≥7 days was associated with an increased risk of BPD (grades 2 and 3) (from 16 to 35%: aRD = 19% (6, 32%), p < 0.005) when infants required ≥10 days of intubation (n = 170). In contrast, there was no significant association between prolonged PDA exposure and BPD when infants required ≤9 days of intubation (aRD = 4%) (-1, 10%) (n = 237).
CONCLUSIONS: Moderate-to-large PDAs are associated with an increased risk of BPD-but only when infants require intubation ≥10 days.