BMC nephrology · 2025
Risk and prognosis of Omicron infection in home-based dialysis patients: a retrospective cohort study in China.
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Gu Wen, Zhou Yijun, Jin Haijiao, Lu Renhua, Fang Wei, Gu Leyi, Wang Qin, Yan Hao, Shao Xinghua, Fang Yan, Li Zhenyuan, Zhang Haifen, Huang Jiaying, Gu Aiping, Gu Jiaqi, Ni Zhaohui
Аннотация
BACKGROUND: Home-based dialysis, including peritoneal dialysis (PD) and home hemodialysis (HHD), has been suggested to reduce SARS-CoV-2 infection rates and improve outcomes compared to in-center dialysis, yet evidence from China remains scarce.
OBJECTIVE: To investigate the risk and prognosis of Omicron infection among patients receiving home-based dialysis versus in-center dialysis during the Omicron surge in Shanghai, China.
METHODS: This single-center retrospective cohort study included patients undergoing maintenance dialysis (home-based dialysis or in-center dialysis) at Ren Ji Hospital from December 1, 2022, to January 31, 2023. The primary endpoint was Omicron infection rate; secondary endpoints included infection timeline, all-cause mortality, and associated risk factors. Logistic regression was used to identify independent predictors.
RESULTS: A total of 465 patients were included: 267 in the home-based dialysis group (263 PD, 4 HHD) and 198 in the in-center dialysis group. The infection rate was significantly lower in the home-based dialysis group than in the in-center dialysis group (52.1% vs. 88.4%, P < .001). Home-based dialysis was an independent protective factor against infection. No significant difference was found in all-cause mortality between home-based dialysis and in-center dialysis groups (5.2% vs. 7.6%, P = .304). Advanced age, heart failure, and low serum albumin were associated with increased risk of death following infection.
CONCLUSIONS: Home-based dialysis significantly reduced the risk of Omicron infection without adversely affecting survival outcomes. Expanding home-based dialysis may have public health implications for dialysis care during future pandemics.
OBJECTIVE: To investigate the risk and prognosis of Omicron infection among patients receiving home-based dialysis versus in-center dialysis during the Omicron surge in Shanghai, China.
METHODS: This single-center retrospective cohort study included patients undergoing maintenance dialysis (home-based dialysis or in-center dialysis) at Ren Ji Hospital from December 1, 2022, to January 31, 2023. The primary endpoint was Omicron infection rate; secondary endpoints included infection timeline, all-cause mortality, and associated risk factors. Logistic regression was used to identify independent predictors.
RESULTS: A total of 465 patients were included: 267 in the home-based dialysis group (263 PD, 4 HHD) and 198 in the in-center dialysis group. The infection rate was significantly lower in the home-based dialysis group than in the in-center dialysis group (52.1% vs. 88.4%, P < .001). Home-based dialysis was an independent protective factor against infection. No significant difference was found in all-cause mortality between home-based dialysis and in-center dialysis groups (5.2% vs. 7.6%, P = .304). Advanced age, heart failure, and low serum albumin were associated with increased risk of death following infection.
CONCLUSIONS: Home-based dialysis significantly reduced the risk of Omicron infection without adversely affecting survival outcomes. Expanding home-based dialysis may have public health implications for dialysis care during future pandemics.