American journal of reproductive immunology (New York, N.Y. : 1989) · 2014
Transcobalamin II (TCN2 67A>G and TCN2 776C>G) and transcobalamin II receptor (TCblR 1104C>T) polymorphisms in Korean patients with idiopathic recurrent spontaneous abortion.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Kim Hyun Seok, Lee Bo Eun, Jeon Young Joo, Rah HyungChul, Lee Woo Sik, Shin Ji Eun, Choi Dong Hee, Kim Nam Keun
Аннотация
PROBLEM: The transcobalamin II (TCN2) 776C>G polymorphism has been reported to be a genetic risk factor for idiopathic recurrent spontaneous abortion (RSA). However, the sample size in previous studies was small, and other TCN2 polymorphisms have not been studied. Moreover, the TCN2 67A>G and 776C>G polymorphisms, and the transcobalamin II receptor (TCblR/CD320) 1104C>T polymorphism, have demonstrated associations with immune responses.
METHOD OF STUDY: Three hundred and seventy-eight RSA patients who had at least two consecutive spontaneous abortions were enrolled. Two hundred and seven control subjects were collected from a convenience sample. Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the TCN2 67A>G and 776C>G polymorphisms, and the TCblR 1104C>T polymorphism.
RESULTS: RSA patients showed significantly different frequencies of the TCN2 67AG+GG genotypes compared with control subjects.
CONCLUSION: The TCN2 67G allele is a possible risk factor for idiopathic RSA.
METHOD OF STUDY: Three hundred and seventy-eight RSA patients who had at least two consecutive spontaneous abortions were enrolled. Two hundred and seven control subjects were collected from a convenience sample. Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the TCN2 67A>G and 776C>G polymorphisms, and the TCblR 1104C>T polymorphism.
RESULTS: RSA patients showed significantly different frequencies of the TCN2 67AG+GG genotypes compared with control subjects.
CONCLUSION: The TCN2 67G allele is a possible risk factor for idiopathic RSA.