Comparative evaluation of red blood cell storage lesion in red cell concentrates (RCCs) prepared from regular and first-time blood donors.

INTRODUCTION

Donor variation is one of the important factor can effect on RBC storage lesion. Consequently, it is possible that the frequency of blood donation can be effective in this regard. Given the few studies that have been conducted, the aim of this study is to compare red blood cell storage damage in two groups of repeat and first-time donors.

RESEARCH DESIGN AND

METHODS

Ten red blood cell concentrates (RCCs) were collected from first-time and ten RCCs from regular blood donors. RCCs were stored for up to 42 days at 2-6°C. Research parameters were performed in both groups during RCCs storage.

RESULTS

Nitric oxide metabolites and Na+ concentration were significantly decreased (p = 0.001), while LDH activity and K+ concentration were increased (p = 0.001) in the RCCs from regular compared to the first-time donors. In both groups, lipid peroxidation, lactate, and hemolysis increased while total antioxidant, pH and glucose concentration showed a decreasing trend during RCCs storage.

CONCLUSION

It seems that the RBC storage lesion in RCCs from regular donors is much more than the first-time donors. Therefore, due to the importance of regular blood donors to supply the required blood, further studies need to investigate the causes of this issue.