Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2009
[VEGF, COX-2 and MVD in lesions of patients with condyloma acuminatum].
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Liu Tong, Zhang Hong-hui
Аннотация
OBJECTIVE: To determine the roles of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) in the occurrence and development of condyloma acuminatum (CA).
METHODS: The VEGF, COX-2, and microvascular density (MVD) in the lesions of 61 CA patients were detected with immunohistochemical SP method. Seventeen skin tissues from healthy men served as controls.
RESULTS: The CA patients had greater positive rate and field-strength scores of VEGF and COX-2 than the controls (P < 0.05). VEGF positively correlated with COX-2 in the CA lesions (r = 0.749, P < 0.05). With the increase of number and diameters of CA lesions, the field-strength scores of VEGF and COX-2 increased (P < 0.05). The positive rates and field-strength scores did not change with the courses of the CA disease (P > 0.05). The CA lesions also had greater MVD than the controls (P < 0.05). The CA lesions with positive VEGF and COX-2 had greater MVD than those with negative VEGF and COX-2 (P < 0.05). Both VEGF and COX-2 were positively correlated with MVD (r = 0.348 and 0.327 respectively, P < 0.05).
CONCLUSION: VEGF and COX-2 promote the abnormal angiogenesis and the cell proliferation in CA lesions, which accelerate the progress of wart lesions. The two factors have synergistic
METHODS: The VEGF, COX-2, and microvascular density (MVD) in the lesions of 61 CA patients were detected with immunohistochemical SP method. Seventeen skin tissues from healthy men served as controls.
RESULTS: The CA patients had greater positive rate and field-strength scores of VEGF and COX-2 than the controls (P < 0.05). VEGF positively correlated with COX-2 in the CA lesions (r = 0.749, P < 0.05). With the increase of number and diameters of CA lesions, the field-strength scores of VEGF and COX-2 increased (P < 0.05). The positive rates and field-strength scores did not change with the courses of the CA disease (P > 0.05). The CA lesions also had greater MVD than the controls (P < 0.05). The CA lesions with positive VEGF and COX-2 had greater MVD than those with negative VEGF and COX-2 (P < 0.05). Both VEGF and COX-2 were positively correlated with MVD (r = 0.348 and 0.327 respectively, P < 0.05).
CONCLUSION: VEGF and COX-2 promote the abnormal angiogenesis and the cell proliferation in CA lesions, which accelerate the progress of wart lesions. The two factors have synergistic