Journal of affective disorders · 2026
Association of age and cardiometabolic risk factors with cardiac diastolic function change in patients with bipolar disorder.
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Hsiao Cheng-Yi, Lin Yen-Kuang, Lai Hsin-Yi, Hsieh Kevin Li-Chun, Chung Kuo-Hsuan, Chiang Shuo-Ju, Tsai Shang-Ying, Chen Pao-Huan
Аннотация
BACKGROUND: Asymptomatic diastolic dysfunction is associated with heart failure and reduced survival. Few studies have evaluated the cardiac diastolic function of patients with bipolar disorder (BD) or examined the risk factors associated with asymptomatic diastolic dysfunction.
METHODS: A total of 127 individuals (65 BD and 62 mentally healthy controls) under age 45 without a clinical diagnosis of heart failure were recruited to undergo conventional and speckle-tracking echocardiography. Echocardiographic procedures were performed in accordance with the recommendations of the American Society of Echocardiography. Cardiometabolic risk factors were obtained using standard in-hospital examinations.
RESULTS: Compared with the mentally healthy group, the BD group had significantly lower values of E velocity (Cohen d = 0.40), septal e' velocity (Cohen d = 0.65), average e' velocity (Cohen d = 0.41), and E/A ratio (Cohen d = 0.42) and a higher value (i.e., greater impairment) of left atrial conduit strain (Cohen d = 0.38). Multiple linear regression analysis revealed that age, diastolic blood pressure, serum fasting insulin, homeostasis model assessment of insulin resistance, and body mass index were significantly associated with poorer diastolic function in the BD group, whereas lithium use was associated with better diastolic function and a lower left ventricular mass index.
CONCLUSION: Increased age and cardiometabolic risk factors are associated with poorer diastolic function in individuals with BD. The findings underscore the importance of integrating proactive cardiometabolic interventions into mental health-care programs designed for this at-risk group.
METHODS: A total of 127 individuals (65 BD and 62 mentally healthy controls) under age 45 without a clinical diagnosis of heart failure were recruited to undergo conventional and speckle-tracking echocardiography. Echocardiographic procedures were performed in accordance with the recommendations of the American Society of Echocardiography. Cardiometabolic risk factors were obtained using standard in-hospital examinations.
RESULTS: Compared with the mentally healthy group, the BD group had significantly lower values of E velocity (Cohen d = 0.40), septal e' velocity (Cohen d = 0.65), average e' velocity (Cohen d = 0.41), and E/A ratio (Cohen d = 0.42) and a higher value (i.e., greater impairment) of left atrial conduit strain (Cohen d = 0.38). Multiple linear regression analysis revealed that age, diastolic blood pressure, serum fasting insulin, homeostasis model assessment of insulin resistance, and body mass index were significantly associated with poorer diastolic function in the BD group, whereas lithium use was associated with better diastolic function and a lower left ventricular mass index.
CONCLUSION: Increased age and cardiometabolic risk factors are associated with poorer diastolic function in individuals with BD. The findings underscore the importance of integrating proactive cardiometabolic interventions into mental health-care programs designed for this at-risk group.