Neuropsychopharmacology reports · 2022
A case report: Clozapine-induced leukopenia and neutropenia after mRNA COVID-19 vaccination.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Imai Tomoyuki, Ochiai Sho, Ishimaru Takehiro, Daitoku Hayato, Miyagawa Yusuke, Fukuhara Ryuji, Boku Shuken, Takebayashi Minoru
Аннотация
Clozapine is an atypical antipsychotic used for treatment-resistant schizophrenia and is known to cause serious side effects, such as leukopenia and neutropenia. We encountered the case of a 44-year-old female patient with a good response to clozapine, who experienced inflammatory reaction and cytopenia after coronavirus disease 2019 (COVID-19) vaccination. Soon after clozapine discontinuation, the inflammatory reaction resolved, and cell counts recovered. There are only a few reports on the interaction between clozapine and COVID-19 vaccine. Our findings suggest that caution is required when a patient who is receiving clozapine scheduled for COVID-19 vaccination, owing to the possibility of cytopenia. Moreover, blood tests and the measurement of clozapine concentration should be performed before and after the inoculation to ensure patient safety.