Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae · 2009
[Relationship between genetic polymorphisms of interferon-gamma gene intron 1 +874 site and recurrent Condyloma acuminata].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Lu Yi-Fan, Zuo Ya-Gang
Аннотация
OBJECTIVE: To explore the relationship between the polymorphisms of interferon-gamma (IFN-gamma) gene intron 1 at position + 874 and Condyloma Acuminata (CA).
METHODS: IFN-gamma gene single nucleotide polymorphisms (intron 1 at position + 874) were detected in 156 subjects, including 76 patients with recurrent CA (CA group) and 80 healthy controls (control group), by polymerase chain reaction with sequence specific primers.
RESULTS: No significant difference of IFN-gamma 1 + 874 was found between CA group (TT, TA, and AA frequencies were 10.5%, 34.2%, and 55.3%, respectively) and control group (TT, TA, and AA frequencies were 7.5%, 30.0%, and 62.5%, respectively) (chi2 = 0.959, P = 0.619).
CONCLUSION: IFN-gamma gene polymorphism (intron 1 at position + 874) is not correlated with recurrent CA.
METHODS: IFN-gamma gene single nucleotide polymorphisms (intron 1 at position + 874) were detected in 156 subjects, including 76 patients with recurrent CA (CA group) and 80 healthy controls (control group), by polymerase chain reaction with sequence specific primers.
RESULTS: No significant difference of IFN-gamma 1 + 874 was found between CA group (TT, TA, and AA frequencies were 10.5%, 34.2%, and 55.3%, respectively) and control group (TT, TA, and AA frequencies were 7.5%, 30.0%, and 62.5%, respectively) (chi2 = 0.959, P = 0.619).
CONCLUSION: IFN-gamma gene polymorphism (intron 1 at position + 874) is not correlated with recurrent CA.