Nationwide surveillance of bacterial pathogens isolated from patients with acute uncomplicated cystitis in 2018: Conducted by the Japanese Research Group for Urinary Tract Infections (JRGU).
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Wada Koichiro, Yokoyama Teruhiko, Uno Satoshi, Araki Motoo, Sadahira Takuya, Maruyama Yuki, Acosta Herik, Nakajima Hirochika, Hiyama Yoshiki, Kunishima Yasuharu, Togo Yoshikazu, Nukaya Takuhisa, Yamada Hiroki, Shigemura Katsumi, Ito Shin, Tanimura Masanobu, Kobayashi Kanao, Kitano Hiroyuki, Teishima Jun, Yasuda Mitsuru, Uehara Shinya, Hamasuna Ryoichi, Watanabe Toyohiko, Nakagawa Tohru, Hayami Hiroshi, Miyazaki Jun, Takahashi Satoshi, Masumori Naoya, Ishikawa Kiyohito, Kiyota Hiroshi, Fujisawa Masato, Arakawa Soichi, Nasu Yasutomo, Yamamoto Shingo
Аннотация
METHODS: We enrolled female patients at least 16 years of age diagnosed with AUC in 2018. Patient information including age, menopausal status, and results of bacteriological examination were collected and analyzed regardless of bacterial identification, antimicrobial susceptibility testing or extended-spectrum β-lactamase (ESBL) detection method.
RESULTS: A total of 847 eligible cases were collected. Escherichia coli (E. coli) was the most frequently isolated bacterial species at about 70%, with proportions of fluoroquinolone-resistant E. coli (QREC) and ESBL-producing E. coli isolates at 15.6% and 9.5% of all E. coli isolates, respectively. The proportion of Staphylococcus saprophyticus (S. saprophyticus) was significantly higher in premenopausal women. Regarding the drug susceptibility of E. coli, isolates from Eastern Japan had significantly higher susceptibility to cefazolin, cefotiam and cefpodoxime and lower susceptibility to levofloxacin in postmenopausal women. ESBL-producing E. coli isolates had a high susceptibility to tazobactam-piperacillin, cefmetazole, carbapenems, aminoglycosides, and fosfomycin. In S. saprophyticus, the susceptibility to β-lactams including carbapenems was 40-60%.
CONCLUSIONS: The proportions of QREC and ESBL-producing E. coli were increasing trends and lower susceptibility to LVFX in postmenopausal women was observed. Such surveillance, consisting of the collecting only clinical data, could be conducted easily and inexpensively. It is expected to be continuously performed as an alternative survey to conventional one collecting bacterial strains.