[Epidemiologic study of changes in vaginal biozoonoses in patients of the Greifswald gynecologic university clinic in the last 25 years].

During a period of 25 years vaginal smears of 96.022 patients of the Gynaecological Clinic of the E.-M.-Arndt-Universität Greifswald were investigated bacterioscopically. As basis for the estimation of the vaginal biocoenosis and for the differentiation between eubiosis and dysbiosis as well as for its graduation (vaginal smear gradings) we used the Gram's staining technique. From 1962-1986 eubiosis increased from 18.8% to 37.9%, whereas the dysbiosis decreased from 81.2% to 62.1%. The reduction of the dysbiotic vaginal flora depends on the continuous decrease of the trichomoniasis from 27.2% to 3% caused by the consequent therapy with metronidazol including the sexual partner. Possibilities for a lowering of the therapy needing dysbiotic bacterial flora are discussed.