Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015
Allergic rhinitis phenotypes based on mono-allergy or poly-allergy.
СтатьяНазвание и аннотация: Перевод в очереди
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Gelardi Matteo, Ciprandi Giorgio, Incorvaia Cristoforo, Buttafava Serena, Leo Eleonora, Iannuzzi Lucia, Quaranta Nicola, Frati Franco
Аннотация
BACKGROUND: Allergic rhinitis (AR) is characterized by typical symptoms that are dependent on inflammation. Poly-allergy is a frequent phenomenon. Phenotyping AR represents an up-to-date issue.
OBJECTIVE: The aim of this study was to evaluate whether the number of allergies is able to define different phenotypes in patients with AR.
METHODS: 83 patients (43 males, mean age 34.7 years) suffering from AR were evaluated. Sensitization, VAS for nasal symptoms perception, and nasal cytology were evaluated.
RESULTS: Poly-allergic patients perceived more severe nasal obstruction than mono-allergic ones (p = 0.0006) as well as they had more frequent sneezing (p < 0.0001). Moreover, poly-allergic patients had a more intense inflammatory infiltrate, concerning both eosinophils (p = 0.0005) and mast cells (p = 0.0001), than mono-allergic patients.
CONCLUSIONS: The present study demonstrates that the presence of poly-allergy could define a distinct AR phenotype in comparison with mono-allergy. It could be clinically relevant as poly-allergic patients have more intense inflammation and more severe symptoms than mono-allergic ones.
OBJECTIVE: The aim of this study was to evaluate whether the number of allergies is able to define different phenotypes in patients with AR.
METHODS: 83 patients (43 males, mean age 34.7 years) suffering from AR were evaluated. Sensitization, VAS for nasal symptoms perception, and nasal cytology were evaluated.
RESULTS: Poly-allergic patients perceived more severe nasal obstruction than mono-allergic ones (p = 0.0006) as well as they had more frequent sneezing (p < 0.0001). Moreover, poly-allergic patients had a more intense inflammatory infiltrate, concerning both eosinophils (p = 0.0005) and mast cells (p = 0.0001), than mono-allergic patients.
CONCLUSIONS: The present study demonstrates that the presence of poly-allergy could define a distinct AR phenotype in comparison with mono-allergy. It could be clinically relevant as poly-allergic patients have more intense inflammation and more severe symptoms than mono-allergic ones.