Reductive Deuteration of Aldehydes/Ketones for the Synthesis of Monodeuterated Phosphinates and Derivatives Using D2O as the Nucleophilic Deuterium Source.

The ideal deuteration, for organic synthetic chemists, might include the use of a cheap deuterium source, mild operating conditions, and diverse transformations. We developed an umpolung sequence for the reductive deuteration of aldehydes/ketones, affording synthetically useful monodeuterated phosphinates. The further one-pot transformation and plausible mechanism of this reaction were studied.