Synthesis of copper hexaferrite magnetic nanoparticles based on carboxymethyl cellulose modified with polyacrylic acid (CMC/PAA/CuFe12O19) for loading and release of Levothyroxine.

Hypothyroidism is a disease that is treated using levothyroxine sodium orally, and its oral use causes some problems in its absorption. A potential alternative to improve its administration is the use of drug delivery systems. This research aimed to prepare CMC/PAA/CuFe12O19 magnetic nano polymer and investigate its performance in the loading and release of Levothyroxine. The CuFe12O19 nanoparticles were synthesized by the co-precipitation method and then CMC/PAA/CuFe12O19 nanopolymer was fabricated to enhance properties. The structure, morphology, magnetic properties, and surface area of CMC/PAA/CuFe12O19 were characterized using different techniques such as XRD, FESEM, VSM, and BET. Levothyroxine was used as a model drug and loading and releasing of Levothyroxine onto CMC/PAA/CuFe12O19 nanopolymer were investigated at pH = 1.2 and pH 7.4. The release of DOX from the CMC/PAA/CuFe12O19 showed a pH-sensitive behavior and released 75 % of Levothyroxine during 3 days at pH = 7.4. The release kinetic analysis, encompassing of Zero order, the First order, the Higuchi, and the Korsmeyer-Peppas models, revealed significant fitting with the First order model at both pH 1.2 (R2 = 0.996) and pH 7.4 (R2 = 0.991) media. Therefore, CMC/PAA/CuFe12O19 nanopolymer could be used as a potential carrier for Levothyroxine delivery.