Dementia and geriatric cognitive disorders · 2008
Cerebral metabolic dysfunction in patients with dementia with Lewy bodies and visual hallucinations.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Perneczky Robert, Drzezga Alexander, Boecker Henning, Förstl Hans, Kurz Alexander, Häussermann Peter
Аннотация
AIMS: To identify the pattern of cerebral hypometabolism in patients with dementia with Lewy bodies (DLB) and visual hallucinations (VH).
METHODS: Fourteen patients with DLB and VH, 7 with DLB without VH and 16 healthy controls underwent clinical and (18)F-FDG PET evaluations. The 2 patient groups did not significantly differ in their clinical characteristics, except in the occurrence of VH. A voxel-wise comparison of (18)F-FDG PET scans was conducted between each of the 2 patient groups and the control group, and the patient groups among each other.
RESULTS: Compared with the control group, hypometabolic regions were more extensive and confluent in the patient group with VH than in the group without VH. The direct comparison between the 2 patient groups revealed a significant metabolic deficit in the group with VH at the right occipito-temporal junction and the right middle frontal gyrus.
CONCLUSIONS: These results suggest that hypometabolism in visual association areas rather than the primary visual cortex is involved in VH in DLB.
METHODS: Fourteen patients with DLB and VH, 7 with DLB without VH and 16 healthy controls underwent clinical and (18)F-FDG PET evaluations. The 2 patient groups did not significantly differ in their clinical characteristics, except in the occurrence of VH. A voxel-wise comparison of (18)F-FDG PET scans was conducted between each of the 2 patient groups and the control group, and the patient groups among each other.
RESULTS: Compared with the control group, hypometabolic regions were more extensive and confluent in the patient group with VH than in the group without VH. The direct comparison between the 2 patient groups revealed a significant metabolic deficit in the group with VH at the right occipito-temporal junction and the right middle frontal gyrus.
CONCLUSIONS: These results suggest that hypometabolism in visual association areas rather than the primary visual cortex is involved in VH in DLB.