American journal of speech-language pathology · 2025
Internet-Based Behavioral Cough Suppression Therapy for Refractory Chronic Cough: A Randomized Controlled Trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Salois Jane R, Heinle Kassidi L, Slovarp Laurie J, Jetté Marie E, Manchaiah Vinaya, Vlaescu George, Andersson Gerhard
Аннотация
PURPOSE: The purpose of this study was to assess the efficacy of internet-based behavioral cough suppression therapy (IBCST) and explore users' experiences.
METHOD: This study involved a prospective, single-blind, randomized controlled trial comparing the efficacy of a 5-week IBCST and healthy lifestyle education control intervention in patients with refractory chronic cough. Additionally, qualitative interviews were conducted and analyzed using grounded theory methodology.
INTERVENTIONS: IBCST and the healthy lifestyle control included 5 weeks of asynchronous content delivered via video and text on a study-specific website. IBCST emphasized education and cough suppression.
OUTCOMES: The Leicester Cough Questionnaire (LCQ) and Cough Severity Visual Analog Scale (VAS) were the primary and secondary outcome measures, respectively, and were administered at baseline (T0), 1-week posttreatment (T1), and 1-month posttreatment (T2). Semistructured qualitative interviews were conducted with a subgroup of IBCST participants.
RESULTS: Thirty-nine adults with refractory chronic cough enrolled, and 30 (27 women, three men; Mage = 61 years) completed the study (18 IBCST, 12 control). IBCST resulted in clinically significant improvements for 72% of participants in LCQ total score at T1 with a mean change of 3.74 (p = .014, ηp2 = .205) and 76% of participants at T2 with a mean change of 4.1 (p = .033, ηp2 = .163). VAS changes did not reach the minimum clinically meaningful threshold but trended in that direction for the IBCST group at T1 (p = .056, ηp2 = .128). Qualitative analysis revealed IBCST participants liked the convenience and quality of treatment and experienced improvements in symptom control.
CONCLUSION: IBCST was feasible and efficacious and resulted in total LCQ score changes on par with what has been reported for other BCST interventions, paving the way for adaptation to a digital therapeutic.
METHOD: This study involved a prospective, single-blind, randomized controlled trial comparing the efficacy of a 5-week IBCST and healthy lifestyle education control intervention in patients with refractory chronic cough. Additionally, qualitative interviews were conducted and analyzed using grounded theory methodology.
INTERVENTIONS: IBCST and the healthy lifestyle control included 5 weeks of asynchronous content delivered via video and text on a study-specific website. IBCST emphasized education and cough suppression.
OUTCOMES: The Leicester Cough Questionnaire (LCQ) and Cough Severity Visual Analog Scale (VAS) were the primary and secondary outcome measures, respectively, and were administered at baseline (T0), 1-week posttreatment (T1), and 1-month posttreatment (T2). Semistructured qualitative interviews were conducted with a subgroup of IBCST participants.
RESULTS: Thirty-nine adults with refractory chronic cough enrolled, and 30 (27 women, three men; Mage = 61 years) completed the study (18 IBCST, 12 control). IBCST resulted in clinically significant improvements for 72% of participants in LCQ total score at T1 with a mean change of 3.74 (p = .014, ηp2 = .205) and 76% of participants at T2 with a mean change of 4.1 (p = .033, ηp2 = .163). VAS changes did not reach the minimum clinically meaningful threshold but trended in that direction for the IBCST group at T1 (p = .056, ηp2 = .128). Qualitative analysis revealed IBCST participants liked the convenience and quality of treatment and experienced improvements in symptom control.
CONCLUSION: IBCST was feasible and efficacious and resulted in total LCQ score changes on par with what has been reported for other BCST interventions, paving the way for adaptation to a digital therapeutic.