European heart journal. Case reports · 2022
With M-protein positive, could transthyretin amyloidosis be easily excluded? Not necessarily! Wild-type transthyretin amyloidosis with Waldenström's macroglobulinaemia: a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Kinoshita Haruyuki, Sugino Hiroshi, Ishikawa Akira, Kido Miki, Kanegawa Munehiro, Kashiwabara Ayano, Sumimoto Yoji, Masada Kenji, Shimonaga Takashi, Oka Toshiharu
Аннотация
BACKGROUND: Generally, it is said that amyloid light-chain (AL) develops not only in multiple myeloma but also in Waldenström's macroglobulinemia. We experienced a case of M-protein positive and diagnosed as wild-type transthyretin amyloidosis (ATTRwt) accompanied with Waldenström's macroglobulinemia.
CASE SUMMARY: The patient was 72-year-old male, and the main complaint was dyspnoea in April 2020 and visited a nearby doctor. He was introduced to the Department of Haematology at our hospital for high levels of serum immunoglobulin M, M-protein positivity, and cardiac hypertrophy with a suspect of AL amyloidosis. Duodenal mucosal biopsy and abdominal skin biopsy showed no amyloid deposits, and left iliac bone marrow biopsy diagnosed Waldenström's macroglobulinemia and with no amyloid, and Kumamoto criteria score 1. Last of all, ATTRwt was diagnosed for endocardial biopsy.
DISCUSSION: This is a very rare case of ATTRwt with Waldenström's macroglobulinaemia.
CASE SUMMARY: The patient was 72-year-old male, and the main complaint was dyspnoea in April 2020 and visited a nearby doctor. He was introduced to the Department of Haematology at our hospital for high levels of serum immunoglobulin M, M-protein positivity, and cardiac hypertrophy with a suspect of AL amyloidosis. Duodenal mucosal biopsy and abdominal skin biopsy showed no amyloid deposits, and left iliac bone marrow biopsy diagnosed Waldenström's macroglobulinemia and with no amyloid, and Kumamoto criteria score 1. Last of all, ATTRwt was diagnosed for endocardial biopsy.
DISCUSSION: This is a very rare case of ATTRwt with Waldenström's macroglobulinaemia.