Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study.
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Ebinger Joseph E, Botwin Gregory J, Albert Christine M, Alotaibi Mona, Arditi Moshe, Berg Anders H, Binek Aleksandra, Botting Patrick, Fert-Bober Justyna, Figueiredo Jane C, Grein Jonathan D, Hasan Wohaib, Henglin Mir, Hussain Shehnaz K, Jain Mohit, Joung Sandy, Karin Michael, Kim Elizabeth H, Li Dalin, Liu Yunxian, Luong Eric, McGovern Dermot P B, Merchant Akil, Merin Noah, Miles Peggy B, Minissian Margo, Nguyen Trevor Trung, Raedschelders Koen, Rashid Mohamad A, Riera Celine E, Riggs Richard V, Sharma Sonia, Sternbach Sarah, Sun Nancy, Tourtellotte Warren G, Van Eyk Jennifer E, Sobhani Kimia, Braun Jonathan G, Cheng Susan
Аннотация
DESIGN: Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires.
SETTINGS: A multisite healthcare delivery system located in Los Angeles County.
PARTICIPANTS: A diverse and unselected population of adults (n=6062) employed in a multisite healthcare delivery system located in Los Angeles County, including individuals with direct patient contact and others with non-patient-oriented work functions.
MAIN OUTCOMES: Using Bayesian and multivariate analyses, we estimated seroprevalence and factors associated with seropositivity and antibody levels, including pre-existing demographic and clinical characteristics; potential COVID-19 illness-related exposures; and symptoms consistent with COVID-19 infection.
RESULTS: We observed a seroprevalence rate of 4.1%, with anosmia as the most prominently associated self-reported symptom (OR 11.04, p<0.001) in addition to fever (OR 2.02, p=0.002) and myalgias (OR 1.65, p=0.035). After adjusting for potential confounders, seroprevalence was also associated with Hispanic ethnicity (OR 1.98, p=0.001) and African-American race (OR 2.02, p=0.027) as well as contact with a COVID-19-diagnosed individual in the household (OR 5.73, p<0.001) or clinical work setting (OR 1.76, p=0.002). Importantly, African-American race and Hispanic ethnicity were associated with antibody positivity even after adjusting for personal COVID-19 diagnosis status, suggesting the contribution of unmeasured structural or societal factors.
CONCLUSION AND RELEVANCE: The demographic factors associated with SARS-CoV-2 seroprevalence among our healthcare workers underscore the importance of exposure sources beyond the workplace. The size and diversity of our study population, combined with robust survey and modelling techniques, provide a vibrant picture of the demographic factors, exposures and symptoms that can identify individuals with susceptibility as well as potential to mount an immune response to COVID-19.