Asian journal of psychiatry · 2025
Effect of quetiapine versus haloperidol on delirium severity in hospitalized adults: A systematic review and meta‑analysis.
Систематический обзорСтатьяМетаанализСравнительное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zainab Shiza, Fatima Eshal, Khalid Muhammad Salman, Tariq Asher, Zaheer Laiba, Abbas Kalsoom, Ahmad Eshan, Sheikh Aamna Raheel, Zakir Eman, Arshad Muhammad Zayd, Sabir Maryam, Zahra Nawal, Kanwal Atifa, Khan Maheen Rehman, Ali Fiza, Razia Isha Tur, Khilji Sabih Qaiser, Ihtasham Aleena, Khan Ahmed Ali, Imran Haider, Hussain Dania, Nasir Anas, Arain Muhammad Saad, Jawed Huzaifa, Najam Sameen
Аннотация
INTRODUCTION: Delirium is a neuropsychiatric condition, characterized by cloudy state of consciousness. Though commonly treated by haloperidol, quetiapine offers its own distinct benefits. A focused systematic review and meta-analysis was performed comparing efficacy of quetiapine with haloperidol in hospitalized adults experiencing delirium.
METHODS: According to PRISMA guidelines, PubMed, Cochrane, Embase and Google scholar were systematically searched. Only RCTs comparing quetiapine and haloperidol monotherapies on adult human patients diagnosed with delirium were included, with delirium severity as primary outcome. A random-effects model was employed for data analysis using Review Manager (RevMan).
RESULTS: 3 RCTs were identified having 215 patients, with 105 receiving quetiapine and 110 receiving haloperidol (mean age ± SD: 57.25 ± 13.09, males: 57.67 %, mean follow up days ± SD: 5.75 ± 1.89). Pooled analysis showed no statistically significant differences in delirium severity (MD: -0.80, 95 % CI: [-2.05, 0.44], I² = 10 %), mortality (RR: 0.60, 95 % CI: [0.29, 1.27, I² = 0 %], sleep time (MD: 1.59, 95 % CI: [-0.45, 3.63], I² = 77 %) and response rate (RR: 0.89, 95 % CI: [0.51, 1.56], I² = 85 %).
CONCLUSION: This study shows no significant difference in overall effect of quetiapine and haloperidol in delirium management. However, due to paucity of RCTs, limited sample size and high heterogeneity, subsequent research is needed to identify optimal pharmacological interventions for delirium management.
METHODS: According to PRISMA guidelines, PubMed, Cochrane, Embase and Google scholar were systematically searched. Only RCTs comparing quetiapine and haloperidol monotherapies on adult human patients diagnosed with delirium were included, with delirium severity as primary outcome. A random-effects model was employed for data analysis using Review Manager (RevMan).
RESULTS: 3 RCTs were identified having 215 patients, with 105 receiving quetiapine and 110 receiving haloperidol (mean age ± SD: 57.25 ± 13.09, males: 57.67 %, mean follow up days ± SD: 5.75 ± 1.89). Pooled analysis showed no statistically significant differences in delirium severity (MD: -0.80, 95 % CI: [-2.05, 0.44], I² = 10 %), mortality (RR: 0.60, 95 % CI: [0.29, 1.27, I² = 0 %], sleep time (MD: 1.59, 95 % CI: [-0.45, 3.63], I² = 77 %) and response rate (RR: 0.89, 95 % CI: [0.51, 1.56], I² = 85 %).
CONCLUSION: This study shows no significant difference in overall effect of quetiapine and haloperidol in delirium management. However, due to paucity of RCTs, limited sample size and high heterogeneity, subsequent research is needed to identify optimal pharmacological interventions for delirium management.