Twin research and human genetics : the official journal of the International Society for Twin Studies · 2020
Self-Reported Symptoms of COVID-19, Including Symptoms Most Predictive of SARS-CoV-2 Infection, Are Heritable.
СтатьяПоддержка исследования: вне правительства СШАTwin StudyНазвание и аннотация: Перевод в очереди
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Williams Frances M K, Freidin Maxim B, Mangino Massimo, Couvreur Simon, Visconti Alessia, Bowyer Ruth C E, Le Roy Caroline I, Falchi Mario, Mompeó Olatz, Sudre Carole, Davies Richard, Hammond Christopher, Menni Cristina, Steves Claire J, Spector Tim D
Аннотация
Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n = 3261) completing the C-19 COVID-19 symptom tracker app allowed classical twin studies of COVID-19 symptoms, including predicted COVID-19, a symptom-based algorithm to predict true infection, derived from app users tested for SARS-CoV-2. We found heritability of 49% (32-64%) for delirium; 34% (20-47%) for diarrhea; 31% (8-52%) for fatigue; 19% (0-38%) for anosmia; 46% (31-60%) for skipped meals and 31% (11-48%) for predicted COVID-19. Heritability estimates were not affected by cohabiting or by social deprivation. The results suggest the importance of host genetics in the risk of clinical manifestations of COVID-19 and provide grounds for planning genome-wide association studies to establish specific genes involved in viral infectivity and the host immune response.