Oral surgery, oral medicine, oral pathology and oral radiology · 2026
Evaluation of bone repair using sticky bone in preradiotherapy extraction sockets of head and neck cancer patients: a pre- and postradiotherapy follow-up.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Rodrigues Jessica Ferreira, Macedo Dhiancarlo Rocha, de Paulo Luiz Fernando Barbosa, Barbosa Gabriella Lopes de Rezende, Faria E Silva André Luís, Soares Carlos José, Soares Priscilla Barbosa Ferreira
Аннотация
PURPOSE: To evaluate the effects of sticky bone a biomaterial composed of Solid-PRF (S-PRF), a variant of platelet-rich fibrin (PRF), and deproteinized bovine bone-on bone formation after tooth extraction performed prior to radiotherapy, with follow-up during both the pre- and postradiotherapy phases.
METHODS: Fifteen patients were randomized to receive either a blood clot (control) or sticky bone (experimental) in each extraction socket. Six patients were followed for up to 60 days after radiotherapy. Clinical assessments included evaluation of the surgical site, whereas bone repair was qualitatively analyzed using radiographs reviewed by three blinded examiners. Data were analyzed using the Mann-Whitney U test, multilevel binary regression, and mixed-effects regression (α = 0.05).
RESULTS: Sticky bone showed no significant effect on the evaluated clinical outcomes, regardless of the assessment period. Improved clinical scores were observed 7 days postoperatively; however, no meaningful differences in soft tissue healing or bone repair were detected within 60 days after radiotherapy.
CONCLUSION: The null hypothesis was accepted: sticky bone had no significant effect on bone or soft tissue healing for up to 60 days after radiotherapy when applied to extraction sites prior to treatment.
METHODS: Fifteen patients were randomized to receive either a blood clot (control) or sticky bone (experimental) in each extraction socket. Six patients were followed for up to 60 days after radiotherapy. Clinical assessments included evaluation of the surgical site, whereas bone repair was qualitatively analyzed using radiographs reviewed by three blinded examiners. Data were analyzed using the Mann-Whitney U test, multilevel binary regression, and mixed-effects regression (α = 0.05).
RESULTS: Sticky bone showed no significant effect on the evaluated clinical outcomes, regardless of the assessment period. Improved clinical scores were observed 7 days postoperatively; however, no meaningful differences in soft tissue healing or bone repair were detected within 60 days after radiotherapy.
CONCLUSION: The null hypothesis was accepted: sticky bone had no significant effect on bone or soft tissue healing for up to 60 days after radiotherapy when applied to extraction sites prior to treatment.