Evaluation of bone repair using sticky bone in preradiotherapy extraction sockets of head and neck cancer patients: a pre- and postradiotherapy follow-up.

PURPOSE: To evaluate the effects of sticky bone a biomaterial composed of Solid-PRF (S-PRF), a variant of platelet-rich fibrin (PRF), and deproteinized bovine bone-on bone formation after tooth extraction performed prior to radiotherapy, with follow-up during both the pre- and postradiotherapy phases.

METHODS

Fifteen patients were randomized to receive either a blood clot (control) or sticky bone (experimental) in each extraction socket. Six patients were followed for up to 60 days after radiotherapy. Clinical assessments included evaluation of the surgical site, whereas bone repair was qualitatively analyzed using radiographs reviewed by three blinded examiners. Data were analyzed using the Mann-Whitney U test, multilevel binary regression, and mixed-effects regression (α = 0.05).

RESULTS

Sticky bone showed no significant effect on the evaluated clinical outcomes, regardless of the assessment period. Improved clinical scores were observed 7 days postoperatively; however, no meaningful differences in soft tissue healing or bone repair were detected within 60 days after radiotherapy.

CONCLUSION

The null hypothesis was accepted: sticky bone had no significant effect on bone or soft tissue healing for up to 60 days after radiotherapy when applied to extraction sites prior to treatment.