Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2012
[Transplanting neural stem cells in nerve conduit to promote rats facial nerve regeneration].
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Shi Yong, Zhou Liang, Tian Jie, Wang Yang
Аннотация
OBJECTIVE: To construct a biodegradable PLGA nerve conduit (NC) filled with NSCs in order to improve facial nerve regeneration.
METHOD: SD rats were subjected to right facial nerve transection, and PLGA NCs filled with NSCs were used to bridge the nerve gap. Facial nerve regeneration was assessed 4 and 12 weeks after surgery, through electrophysiological testing, and morphometric analysis of axons.
RESULT: Nerve action potential amplitude, and axonal area were significantly greater in the NSCs group than the empty NC group.
CONCLUSION: NSCs transplantation may improve regeneration of the facial nerve.
METHOD: SD rats were subjected to right facial nerve transection, and PLGA NCs filled with NSCs were used to bridge the nerve gap. Facial nerve regeneration was assessed 4 and 12 weeks after surgery, through electrophysiological testing, and morphometric analysis of axons.
RESULT: Nerve action potential amplitude, and axonal area were significantly greater in the NSCs group than the empty NC group.
CONCLUSION: NSCs transplantation may improve regeneration of the facial nerve.