The Journal of clinical endocrinology and metabolism · 2017
Trimester-Specific Urinary Bisphenol A Concentrations and Blood Glucose Levels Among Pregnant Women From a Fertility Clinic.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Chiu Yu-Han, Mínguez-Alarcón Lidia, Ford Jennifer B, Keller Myra, Seely Ellen W, Messerlian Carmen, Petrozza John, Williams Paige L, Ye Xiaoyun, Calafat Antonia M, Hauser Russ, James-Todd Tamarra, for EARTH Study Team
Аннотация
CONTEXT: Women with a history of infertility are at increased risk of impaired glucose tolerance during pregnancy. Studies suggest higher urinary bisphenol A (BPA) concentrations are associated with diabetes in nonpregnant populations, but the association between BPA and glucose levels among pregnant women is unclear.
OBJECTIVE: To assess trimester-specific urinary BPA concentrations in relation to blood glucose levels among subfertile women.
DESIGN: Environment and Reproductive Health Study, an ongoing prospective cohort study.
SETTING: A fertility center in a teaching hospital.
PATIENTS: A total of 245 women contributed at least one urine sample during first and/or second trimesters, delivered a singleton or twin pregnancy, and had available blood glucose data (2005 to 2015).
MAIN OUTCOME MEASURE: Blood glucose levels after a nonfasting 50-g glucose challenge test at 24 to 28 weeks of gestation.
RESULTS: The specific gravity-adjusted geometric mean urinary BPA concentrations during first and second trimesters were 1.39 and 1.27 µg/L, respectively. Second-trimester BPA concentrations were positively associated with blood glucose (P, trend = 0.01). Specifically, the adjusted mean glucose levels (95% confidence interval) for women in the highest quartile of second-trimester BPA concentrations was 119 (112, 126) mg/dL compared with 106 (100, 112) mg/dL for women in the lowest quartile. No associations were observed between first-trimester BPA concentrations and glucose levels.
CONCLUSIONS: BPA exposure during the second trimester may have adverse effect on blood glucose levels among subfertile women. As the findings represent the first report suggesting a potential etiologically relevant window for BPA and glucose in humans, further studies are needed.
OBJECTIVE: To assess trimester-specific urinary BPA concentrations in relation to blood glucose levels among subfertile women.
DESIGN: Environment and Reproductive Health Study, an ongoing prospective cohort study.
SETTING: A fertility center in a teaching hospital.
PATIENTS: A total of 245 women contributed at least one urine sample during first and/or second trimesters, delivered a singleton or twin pregnancy, and had available blood glucose data (2005 to 2015).
MAIN OUTCOME MEASURE: Blood glucose levels after a nonfasting 50-g glucose challenge test at 24 to 28 weeks of gestation.
RESULTS: The specific gravity-adjusted geometric mean urinary BPA concentrations during first and second trimesters were 1.39 and 1.27 µg/L, respectively. Second-trimester BPA concentrations were positively associated with blood glucose (P, trend = 0.01). Specifically, the adjusted mean glucose levels (95% confidence interval) for women in the highest quartile of second-trimester BPA concentrations was 119 (112, 126) mg/dL compared with 106 (100, 112) mg/dL for women in the lowest quartile. No associations were observed between first-trimester BPA concentrations and glucose levels.
CONCLUSIONS: BPA exposure during the second trimester may have adverse effect on blood glucose levels among subfertile women. As the findings represent the first report suggesting a potential etiologically relevant window for BPA and glucose in humans, further studies are needed.