Frontiers in medicine · 2025
Variations in capillary and serum lactates levels based on different etiologies of septic patients in the emergency department.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Guarino Matteo, Perna Benedetta, Maroncelli Giacomo, Baldin Paolo, Donati Chiara, Luppi Francesco, Cesaro Alice Eleonora, Pesci Chiara, Costanzini Anna, Maritati Martina, Clavenzani Paolo, Contini Carlo, De Giorgio Roberto, Spampinato Michele Domenico
Аннотация
INTRODUCTION: Sepsis is a life-threating and time-depending condition. This study examined the association between sepsis etiology and variations in capillary and serum lactate levels, neutrophil-to-lymphocyte ratio, and diastolic shock index in emergency department patients.
METHODS: This study, conducted between 2021 and 2022 at the Emergency Department of Ferrara, included the following criteria: (i) clinical suspect of infectious disease; (ii) qSOFA ≥2; (iii) age ≥18 years; (iv) signed informed consent. Etiologies were: (i) negative cultures (NC); (ii) Gram positive (GP); (iii) Gram negative (GN); (iv) fungal infections (FI).
RESULTS: Among the 200 included patients, 104 (52.0%) had NC, 36 (18.0%) GP, 53 (26.5%) GN and 7 (3.5%) FI. CLs (p = 0.006) and SLs (p < 0.001) were different according to etiology being higher in GP infections. NLR (p = 0.035) was higher in GN infections, while DSI (p = 0.008) increased in FI. Mortality was not influenced by the etiology.
CONCLUSION: All parameters differed according to sepsis etiology, thus improving early prediction of sepsis etiology and its pharmacological management.
METHODS: This study, conducted between 2021 and 2022 at the Emergency Department of Ferrara, included the following criteria: (i) clinical suspect of infectious disease; (ii) qSOFA ≥2; (iii) age ≥18 years; (iv) signed informed consent. Etiologies were: (i) negative cultures (NC); (ii) Gram positive (GP); (iii) Gram negative (GN); (iv) fungal infections (FI).
RESULTS: Among the 200 included patients, 104 (52.0%) had NC, 36 (18.0%) GP, 53 (26.5%) GN and 7 (3.5%) FI. CLs (p = 0.006) and SLs (p < 0.001) were different according to etiology being higher in GP infections. NLR (p = 0.035) was higher in GN infections, while DSI (p = 0.008) increased in FI. Mortality was not influenced by the etiology.
CONCLUSION: All parameters differed according to sepsis etiology, thus improving early prediction of sepsis etiology and its pharmacological management.