Relationship between plasma antidiuretic hormone and atrial natriuretic peptide during the triphasic diuresis response to experimentally induced acute intracranial hypertension.

Plasma antidiuretic hormone (pADH) and atrial natruiretic peptide (pANP) were determined during the triphasic diuresis response to acute cerebral compression in cats. The first, the polyuric phase, was accompanied by the cardiovascular response, characterized by a simultaneous increase of pADH and pANP. During the second, the oliguric phase and the third phase of diabetes insipidus pADH and pANP concentrations decreased to initial values. These changes were accompanied by symptoms of central vegetative dysregulation namely hypotension, respiratory arrest and EEG cessation. Thus, the results exhibited the same pattern of vasopressinergic and atriopeptinergic activities after induction of an acute intracranial hypertension and suggest that the mutual interaction of both systems may modify the type of diuresis response.