International journal of ophthalmology · 2025
Dynamic changes of spontaneous brain activity in patients after LASIK: a resting-state fMRI study.
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Zhang Hui, Xu Zi-Song, Hu Jin-Yu, Liu Zhen-Zhe, Zhong Lei, He Liang-Qi, Chen Cheng, Wang Xiao-Yu, Wei Hong, Zeng Yan-Mei, Ling Qian, Chen Xu, Wang Yi-Xin, Shao Yi
Аннотация
AIM: To investigate changes in local brain activity after laser assisted in situ keratomileusis (LASIK) in myopia patients, and further explore whether post-LASIK (POL) patients and healthy controls (HCs) can be distinguished by differences in dynamic amplitude of low-frequency fluctuations (dALFF) in specific brain regions.
METHODS: The resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 15 myopic patients who underwent LASIK and 15 matched healthy controls. This method was selected to calculate the corresponding dALFF values of each participant, to compare dALFF between the groups and to determine whether dALFF distinguishes reliably between myopic patients after LASIK and HCs using the linear support vector machine (SVM) permutation test (5000 repetitions).
RESULTS: dALFF was lower in POL than in HCs at the right precentral gyrus and right insula. Classification accuracy of the SVM was 89.1% (P<0.001).
CONCLUSION: The activity of spontaneous neurons in the right precentral gyrus and right insula of myopic patients change significantly after LASIK. SVM can correctly classify POL patients and HCs based on dALFF differences.
METHODS: The resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 15 myopic patients who underwent LASIK and 15 matched healthy controls. This method was selected to calculate the corresponding dALFF values of each participant, to compare dALFF between the groups and to determine whether dALFF distinguishes reliably between myopic patients after LASIK and HCs using the linear support vector machine (SVM) permutation test (5000 repetitions).
RESULTS: dALFF was lower in POL than in HCs at the right precentral gyrus and right insula. Classification accuracy of the SVM was 89.1% (P<0.001).
CONCLUSION: The activity of spontaneous neurons in the right precentral gyrus and right insula of myopic patients change significantly after LASIK. SVM can correctly classify POL patients and HCs based on dALFF differences.