The relationship between erectile dysfunction and blood urea nitrogen/creatinine and blood urea nitrogen/albumin ratios: A case-control study.

INTRODUCTION

Blood urea nitrogen (BUN)/creatinine (Cr) and BUN/albumin ratios are used in the evaluation of many diseases that can be associated with ED. The aim of this study was to examine the relationship between ED and BUN/Cr and BUN/albumin ratios and compare them to healthy peers.

MATERIAL AND

METHODS

Total of 1,664 patients diagnosed with ED between January 2020 and August 2024 were accessed and retrospectively examined. Six hundred and seventy-two male patients with IIEF-5 score below 22 and complaining of ED were included in the study. Ninety-six patients without ED complaints were selected as the control group. Control and ED groups were compared in terms of BUN/Cr and BUN/Albumin ratio values and other biochemical and hormonal parameters.

RESULTS

BUN/Cr value was calculated as 27.63 ±12.3 in the ED group and 17.52 ±5.1 in the control group (p <0.001). The AUC value of this ratio was calculated as 0.745 and its sensitivity was found to be 32% and specificity was found to be 98%. BUN/albumin ratio was calculated as 6.03 ±5.8 in the ED group and 3.54 ±1.2 in the control group (p <0.001). The AUC value of this ratio was found to be 0.718, its sensitivity was 43% and its specificity was 98%. The BUN/Cr ratio of all ED subgroups was significantly higher than control group, and BUN/albumin value was significantly higher in mild, moderate and severe groups.

CONCLUSIONS

In this study, it was calculated that the risk of ED was higher in patients with BUN/Cr ratio >33.92 and BUN/albumin ratio >5.80, and both values had high specificity.