Медицинская библиотека · Digestive diseases and sciences · 2014

Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population.

Xu Chao, Chen Pingfa, Xie Hua, Zhu Hairong, Zhu Dongmei, Cai Peng, Huo Weiwei, Qin Yufeng, Li Hongxing, Xia Yankai, Tang Weibing

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

Previous studies suggested that cytochrome P450 participated in the tumor metastasis and migration. CYP2B6 also acts as an important enzyme which metabolize partially or primarily metabolism of drugs, environmental contaminants, and mutagens. The objective of this study was to investigate the influence of CYP2B6 polymorphism on susceptibility of Hirschsprung disease.

METHODS

TaqMan assay was performed to determine the genotypes of CYP2B6 rs707265, rs1042389, rs2054675 in 262 cases and 290 control subjects. Logistic regression was used to assess the associations between these polymorphisms and HSCR.

RESULTS

We observed a significant association of CYP2B6 rs707265 (G>A) polymorphism and HSCR susceptibility (p < 0.001). Besides, rs707265 A presented a significant risk of HSCR (p < 0.001).

CONCLUSIONS

Our result suggested that CYP2B6 rs707265 modified the risk of HSCR.

Для цитирования: Xu Chao, Chen Pingfa, Xie Hua, Zhu Hairong, Zhu Dongmei, Cai Peng, Huo Weiwei, Qin Yufeng, Li Hongxing, Xia Yankai, Tang Weibing. Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population.. Digestive diseases and sciences. 2014. DOI: 10.1007/s10620-014-3450-6.

Предметные рубрики MeSH

Asian People Case-Control Studies China Cytochrome P-450 CYP2B6 Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Hirschsprung Disease Humans Logistic Models Odds Ratio Phenotype Polymorphism, Genetic Risk Factors

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