Schizophrenia research · 2005
FOXP2 polymorphisms in patients with schizophrenia.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Sanjuan Julio, Tolosa Amparo, González Jose Carlos, Aguilar Eduardo Jesus, Moltó Maria Dolores, Nájera Carmen, de Frutos Rosa
Аннотация
BACKGROUND: FOXP2 was described as the first gene involved in our ability to acquire spoken language. The main objective of this study was to compare the distribution of FOXP2 gene polymorphisms between patients with schizophrenia and healthy controls.
METHODS: Two FOXP2 polymorphisms, Intron3a and SNP 923875, and the G-->A transition in exon 14 were analysed in 149 patients with schizophrenia and schizoaffective disorders according to DSM-IV, as well as in 137 controls. All the patients showed a history of auditory hallucinations.
RESULTS: The transition G-->A at exon 14, detected in all the affected members in KE family, was not found in any of the analyzed samples from patients or controls. No significant differences were found between individual controls and patients for the two analysed polymorphisms.
CONCLUSIONS: This study would not support a possible role of the two FOXP2 analyzed polymorphisms in the vulnerability to schizophrenia.
METHODS: Two FOXP2 polymorphisms, Intron3a and SNP 923875, and the G-->A transition in exon 14 were analysed in 149 patients with schizophrenia and schizoaffective disorders according to DSM-IV, as well as in 137 controls. All the patients showed a history of auditory hallucinations.
RESULTS: The transition G-->A at exon 14, detected in all the affected members in KE family, was not found in any of the analyzed samples from patients or controls. No significant differences were found between individual controls and patients for the two analysed polymorphisms.
CONCLUSIONS: This study would not support a possible role of the two FOXP2 analyzed polymorphisms in the vulnerability to schizophrenia.
Предметные рубрики MeSH
AdultAgedAllelesDNA PrimersDiagnostic and Statistical Manual of Mental DisordersExonsFemaleForkhead Transcription FactorsGenetic Predisposition to DiseaseGenotypeHallucinationsHumansIntronsLanguage DisordersMaleMiddle AgedPolymorphism, GeneticRetrospective StudiesSchizophreniaSeverity of Illness IndexTranscription Factors