[Study on effects of Codonopsis eupolyphaga anti-obesity powder in mice with nutritive obesity].

OBJECTIVE

To observe the effects of Codonopsis Eupolyphaga anti-obesity powder(CEAOP) in mice with nutritive obesity.

METHODS

CEAOP 0.5-2.5 g/kg was given to mice for 4 weeks and its effect was observed.

RESULTS

CEAOP could significantly reduce the Lee's index, weight of fat cushion and fat index, lower the blood levels of total cholesterol, triglyceride and blood glucose, but influence neither the calories and quantity of food intake, nor the endurance against anoxia and fatigue, the property of stool was not changed at all.

CONCLUSIONS

The anti-obesity effect of CEAOP was similar to Fenfluramini but without influence on appetite and bowel movement, tolerance against anoxia and fatigue. The mechanism of the anti-obesity might be related with its metabolism regulating actions on lipids and glucose.