[Cyclic adenosine monophosphate metabolism in the peripheral blood lymphocytes of atopic patients exposed to histamine].

Radioisotopic assay has shown that in vitro histamine increases the metabolism of cyclic adenosine monophosphate (cAMP) through H-2 receptors in the peripheral blood lymphocytes of healthy individuals and patients with atopic bronchial asthma. In patients who have asphyxia the histamine-induced stimulation of the activity of cAMP phosphodiesterase metabolizing cAMP is considerably decreased. In is suggested that high cAMP metabolism may be a cause of desensitization of histaminic and adrenergic receptors in atopy whose aggravation is accompanied by histaminemia.