Multiple sclerosis (Houndmills, Basingstoke, England) · 2022
Progressive myelin oligodendrocyte glycoprotein-associated demyelination mimicking leukodystrophy.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Gibbons Emily, Whittam Daniel, Elhadd Kariem, Bhojak Maneesh, Rathi Nitika, Avula Shivaram, Jacob Anu, Griffiths Michael, Huda Saif
Аннотация
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with relapsing disease, but clinical progression independent of relapse activity is rare.
OBJECTIVES: To report progressive disease in a patient with MOGAD.
METHODS: A single retrospective case report.
RESULTS: At 4 years of age, the patient had a single episode of acute disseminated encephalomyelitis. She remained well until age 17 years but over the next 9 years developed progressive spastic quadriparesis, cognitive and bulbar dysfunction. Brain imaging showed a leukodystrophy-like pattern of white matter abnormality with contrast enhancement at different time points. Myelin oligodendrocyte glycoprotein (MOG)-IgG was repeatedly positive by live cell-based assay.
CONCLUSION: Secondary progression may be a rare presentation of MOG-IgG-associated disease.
OBJECTIVES: To report progressive disease in a patient with MOGAD.
METHODS: A single retrospective case report.
RESULTS: At 4 years of age, the patient had a single episode of acute disseminated encephalomyelitis. She remained well until age 17 years but over the next 9 years developed progressive spastic quadriparesis, cognitive and bulbar dysfunction. Brain imaging showed a leukodystrophy-like pattern of white matter abnormality with contrast enhancement at different time points. Myelin oligodendrocyte glycoprotein (MOG)-IgG was repeatedly positive by live cell-based assay.
CONCLUSION: Secondary progression may be a rare presentation of MOG-IgG-associated disease.