Journal of biomedical optics · 2026
Dual-resolution megahertz optical coherence tomography prototype rectoscope for enhanced visualization of colorectal microstructures.
СтатьяНазвание и аннотация: Перевод в очереди
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Burhan Sazgar, Schulte Berenice, Göb Madita, Singh Awanish Pratap, Mustafa Bayan, Lotz Simon, Draxinger Wolfgang, Lamminger Philipp, Saker Yasmeine, Eixmann Tim, Ahrens Martin, Heimke Marvin, Heinze Tillmann, Wedel Thilo, Rahlves Maik, Ellrichmann Mark, Huber Robert
Аннотация
SIGNIFICANCE: Endoscopic optical coherence tomography (OCT) is a valuable tool for rectal imaging, enabling noninvasive visualization of transmural structures with near-histological resolution, critical for accurate tumor staging and diagnostic/therapeutic monitoring. However, anatomical variability of the rectum and the resulting changes in tissue-to-probe distance challenge optimal circumferential imaging.
AIM: We aim to develop a dual-mode endoscopic OCT system, enabling real-time switching between high-detail and extended-range imaging for improved assessment of rectal wall morphology under varying anatomical conditions.
APPROACH: A single fiber-optic ferrule containing two fibers with differing mode fields was integrated into a MHz-OCT rectoscope, enabling an extended-range mode for full circumferential imaging and a high-detail mode for close examination of fine structures with seamless live switching mechanism. The system was tested in situ on a postmortem human rectum preserved with ethanol-glycerol-lysoformin fixation.
RESULTS: Postmortem rectum imaging demonstrated the feasibility of real-time switching between the two modes. Extended-range imaging provided full circumferential coverage, whereas high-detail imaging revealed distinct rectal wall layers and fine transmural structures, validated by histological correlation.
CONCLUSIONS: The dual-mode MHz-OCT system offers a flexible and practical solution for adaptive rectal imaging, providing high-resolution detail and full circumferential coverage with the potential to enhance diagnostics and treatment monitoring.
AIM: We aim to develop a dual-mode endoscopic OCT system, enabling real-time switching between high-detail and extended-range imaging for improved assessment of rectal wall morphology under varying anatomical conditions.
APPROACH: A single fiber-optic ferrule containing two fibers with differing mode fields was integrated into a MHz-OCT rectoscope, enabling an extended-range mode for full circumferential imaging and a high-detail mode for close examination of fine structures with seamless live switching mechanism. The system was tested in situ on a postmortem human rectum preserved with ethanol-glycerol-lysoformin fixation.
RESULTS: Postmortem rectum imaging demonstrated the feasibility of real-time switching between the two modes. Extended-range imaging provided full circumferential coverage, whereas high-detail imaging revealed distinct rectal wall layers and fine transmural structures, validated by histological correlation.
CONCLUSIONS: The dual-mode MHz-OCT system offers a flexible and practical solution for adaptive rectal imaging, providing high-resolution detail and full circumferential coverage with the potential to enhance diagnostics and treatment monitoring.