The Journal of urology · 2000
Review article: The molecular era of bladder research. Transgenic mice as experimental tools in the study of outlet obstruction.
СтатьяПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Bassuk J A, Grady R, Mitchell M
Аннотация
PURPOSE: To review the crucial role of transgenic mice as experimental tools in the study of outlet obstruction.
MATERIALS AND METHODS: We reviewed the literature for studies that have used mice as models for outlet obstruction.
RESULTS: The combination of genetic manipulations and cellular physiology defines state-of-the-art experiments that explore the reciprocal mesenchymal-epithelial interactions that regulate bladder cell mechanisms.
CONCLUSIONS: The use of transgenic mice in bladder research has provided important data with respect to the molecular signals that drive bladder development, homeostasis, and the response to injury.
MATERIALS AND METHODS: We reviewed the literature for studies that have used mice as models for outlet obstruction.
RESULTS: The combination of genetic manipulations and cellular physiology defines state-of-the-art experiments that explore the reciprocal mesenchymal-epithelial interactions that regulate bladder cell mechanisms.
CONCLUSIONS: The use of transgenic mice in bladder research has provided important data with respect to the molecular signals that drive bladder development, homeostasis, and the response to injury.