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DOI 10.2217/pme-2021-0063

Медицинская библиотека · Personalized medicine · 2021

Association study of genetic polymorphisms in GABRD with treatment response and dose in methadone maintenance treatment.

Xie Xiaohu, Gu Jun, Zhuang Dingding, Chen Xiaoyu, Zhou Yun, Shen Wenwen, Li Longhui, Liu Yue, Xu Wenjin, Hong Qingxiao, Chen Weisheng, Zhou Wenhua, Liu Huifen

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Aim: This study determined if gene variants in the GABA receptor delta subunit (GABRD) are associated with treatment response and dose in methadone maintenance treatment (MMT) for heroin addiction. Materials & methods: A total of 286 MMT patients were recruited and divided into response and nonresponse groups based on retention time in therapy. A total of 177 responders were classified into low dose and high dose subgroups according to the stabilized methadone dose. Four (single nucleotide polymorphisms) SNPs (rs13303344, rs4481796, rs2376805 and rs2229110) in GABRD were genotyped using the TaqMan SNP assay. Logistic regression was used to assess the genetic effects of the SNPs in MMT.

Results

No significant associations were observed between the SNPs and treatment response or dose, except the frequency of haplotype ACGC at the four SNPs significantly differed between responders and nonresponders.

Conclusion

The results indicated that GABRD variants may play a small role in modulating methadone treatment response.

Для цитирования: Xie Xiaohu, Gu Jun, Zhuang Dingding, Chen Xiaoyu, Zhou Yun, Shen Wenwen, Li Longhui, Liu Yue, Xu Wenjin, Hong Qingxiao, Chen Weisheng, Zhou Wenhua, Liu Huifen. Association study of genetic polymorphisms in GABRD with treatment response and dose in methadone maintenance treatment.. Personalized medicine. 2021. DOI: 10.2217/pme-2021-0063.

Предметные рубрики MeSH

Heroin DependenceHumansMethadoneOpiate Substitution TreatmentPolymorphism, Single NucleotideReceptors, GABAReceptors, GABA-A
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