American journal of translational research · 2025
Association between SMAD3 and SMAD7 gene polymorphisms and susceptibility to stress urinary incontinence in Chinese women.
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Chen Wenpu, Wang Xingqiong, Yu Chengshuai, Yu Guofeng
Аннотация
OBJECTIVE: This study aimed to investigate the correlation between single nucleotide polymorphisms (SNPs) in SMAD3 and SMAD7 genes and the genetic risk of stress urinary incontinence (SUI) in Chinese women.
METHODS: A case-control study was conducted with 117 women diagnosed with SUI and 103 healthy controls. SNPs in SMAD3 (rs28683050, rs12901499) and SMAD7 (rs12953717, rs4939827) were analyzed using polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). Allele and genotype frequencies were assessed using the SHEsis online platform. Epidemiological, clinical, and laboratory data were collected retrospectively. SUI patients underwent pelvic floor muscle training (PFMT), and treatment outcomes were evaluated after 3 months.
RESULTS: The G allele and GG genotype of rs12901499 in SMAD3 were significantly more common in the SUI case group (p_allele < 0.001, p_genotype = 0.002). Similarly, the T allele and TT genotype at rs12953717 in SMAD7 were more frequent in the SUI case group (p_allele = 0.002, p_genotype = 0.007). Multivariate logistic regression revealed that body mass index (BMI), family history, and the rs12901499 and rs12953717 polymorphisms were significant risk factors for SUI (P < 0.05). Furthermore, the TT genotype at rs12953717 was associated with poorer PFMT treatment outcomes.
CONCLUSION: Our findings suggest that the rs12901499 and rs12953717 polymorphisms are potential risk factors for SUI in women. Additionally, the rs12953717 polymorphism may influence the effectiveness of PFMT in SUI treatment.
METHODS: A case-control study was conducted with 117 women diagnosed with SUI and 103 healthy controls. SNPs in SMAD3 (rs28683050, rs12901499) and SMAD7 (rs12953717, rs4939827) were analyzed using polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). Allele and genotype frequencies were assessed using the SHEsis online platform. Epidemiological, clinical, and laboratory data were collected retrospectively. SUI patients underwent pelvic floor muscle training (PFMT), and treatment outcomes were evaluated after 3 months.
RESULTS: The G allele and GG genotype of rs12901499 in SMAD3 were significantly more common in the SUI case group (p_allele < 0.001, p_genotype = 0.002). Similarly, the T allele and TT genotype at rs12953717 in SMAD7 were more frequent in the SUI case group (p_allele = 0.002, p_genotype = 0.007). Multivariate logistic regression revealed that body mass index (BMI), family history, and the rs12901499 and rs12953717 polymorphisms were significant risk factors for SUI (P < 0.05). Furthermore, the TT genotype at rs12953717 was associated with poorer PFMT treatment outcomes.
CONCLUSION: Our findings suggest that the rs12901499 and rs12953717 polymorphisms are potential risk factors for SUI in women. Additionally, the rs12953717 polymorphism may influence the effectiveness of PFMT in SUI treatment.