Biomarkers in medicine · 2026
A meta-analysis of the clinical significance of red blood cell distribution width in chronic obstructive pulmonary disease.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод в очереди
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Zeng Yi, Ma Zhipeng, Liu Keliang, Zheng Wei, Ma Jianli, Wang Hualing, Zhang Chuantao
Аннотация
BACKGROUND: This paper aims to elucidate the association of red blood cell distribution width (RDW) with chronic obstructive pulmonary disease (COPD) and its clinical outcomes.
METHODS: Systematically searched PubMed, Embase, Cochrane Library, and Web of Science for articles up to 11 October 2024, and conducted a comprehensive data integration and meta-analysis.
RESULTS: 41 articles with 19,518 participants were included. RDW was higher in COPD versus non-COPD patients (SMD = 0.63, 95% CI = 0.18 ~ 1.08); in AECOPD versus stable COPD (SMD = 0.39, 95% CI = 0.21 ~ 0.57); in COPD with complications (SMD = 0.50, 95% CI = 0.32 ~ 0.68); in deceased versus surviving patients (SMD = 0.63, 95% CI = 0.38 ~ 0.89); and in those with unfavorable outcomes (SMD = 1.21, 95% CI = 0.17 ~ 2.25). Increased RDW was linked to adverse outcomes (OR =1.32, 95% CI = 1.18 ~ 1.48) and predicted mortality (AUC = 0.68, 95% CI = 0.57 ~ 0.80) and other adverse outcomes (AUC = 0.76, 95% CI = 0.67 ~ 0.85) in COPD patients.
CONCLUSIONS: RDW values differed markedly between COPD and non-COPD patients and among COPD patients of different severities and clinical outcomes, and was an independent predictor of mortality and complication risks.
METHODS: Systematically searched PubMed, Embase, Cochrane Library, and Web of Science for articles up to 11 October 2024, and conducted a comprehensive data integration and meta-analysis.
RESULTS: 41 articles with 19,518 participants were included. RDW was higher in COPD versus non-COPD patients (SMD = 0.63, 95% CI = 0.18 ~ 1.08); in AECOPD versus stable COPD (SMD = 0.39, 95% CI = 0.21 ~ 0.57); in COPD with complications (SMD = 0.50, 95% CI = 0.32 ~ 0.68); in deceased versus surviving patients (SMD = 0.63, 95% CI = 0.38 ~ 0.89); and in those with unfavorable outcomes (SMD = 1.21, 95% CI = 0.17 ~ 2.25). Increased RDW was linked to adverse outcomes (OR =1.32, 95% CI = 1.18 ~ 1.48) and predicted mortality (AUC = 0.68, 95% CI = 0.57 ~ 0.80) and other adverse outcomes (AUC = 0.76, 95% CI = 0.67 ~ 0.85) in COPD patients.
CONCLUSIONS: RDW values differed markedly between COPD and non-COPD patients and among COPD patients of different severities and clinical outcomes, and was an independent predictor of mortality and complication risks.