International journal of nanomedicine · 2011
Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells.
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Fekrazad Reza, Hakimiha Neda, Farokhi Enice, Rasaee Mohammad Javad, Ardestani Mehdi Shafiee, Kalhori Katayoun A M, Sheikholeslami Farzaneh
Аннотация
BACKGROUND: Worldwide, oral squamous cell carcinoma (potentially mediated by HER2) is recognized as the most commonly occurring malignant neoplasm of the oral cavity. Anti-HER2 nanobodies conjugated to gold-silica nanoshells and used as photothermal treatment for oral squamous cell carcinoma may provide a novel therapeutic alternative to current treatment for this disease.
METHODS: KB epithelial or HeLaS3 cell cultures (controls) were exposed to these immunonanoshells, and plasmon resonance electron initiation specific to gold was employed to burn the tumor cells.
RESULTS: Following this treatment, significant cell death occurred in the KB tumor cell cultures while there was no evidence of cellular damage or death in the HeLaS3 cell cultures.
CONCLUSION: These findings suggest that photothermal treatment of oral squamous cell carcinoma has considerable advantages.
METHODS: KB epithelial or HeLaS3 cell cultures (controls) were exposed to these immunonanoshells, and plasmon resonance electron initiation specific to gold was employed to burn the tumor cells.
RESULTS: Following this treatment, significant cell death occurred in the KB tumor cell cultures while there was no evidence of cellular damage or death in the HeLaS3 cell cultures.
CONCLUSION: These findings suggest that photothermal treatment of oral squamous cell carcinoma has considerable advantages.