Features of Mild-to-Moderate COVID-19 Patients With Dysphonia.
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Lechien Jerome R, Chiesa-Estomba Carlos M, Cabaraux Pierre, Mat Quentin, Huet Kathy, Harmegnies Bernard, Horoi Mihaela, Le Bon Serge Daniel, Rodriguez Alexandra, Dequanter Didier, Hans Stéphane, Crevier-Buchman Lise, Hochet Baptiste, Distinguin Lea, Chekkoury-Idrissi Younes, Circiu Marta, El Afia Fahd, Barillari Maria Rosaria, Cammaroto Giovanni, Fakhry Nicolas, Michel Justin, Radulesco Thomas, Martiny Delphine, Lavigne Philippe, Jouffe Lionel, Descamps Géraldine, Journe Fabrice, Trecca Eleonora M C, Hsieh Julien, Delgado Irene Lopez, Calvo-Henriquez Christian, Vergez Sebastien, Khalife Mohamad, Molteni Gabriele, Mannelli Giuditta, Cantarella Giovanna, Tucciarone Manuel, Souchay Christel, Leich Pierre, Ayad Tareck, Saussez Sven
Аннотация
METHODS: The clinical and epidemiological data of 702 patients with mild-to-moderate COVID-19 were collected from 19 European Hospitals. The following data were extracted: age, sex, ethnicity, tobacco consumption, comorbidities, general, and otolaryngological symptoms. Dysphonia and otolaryngological symptoms were self-assessed through a 4-point scale. The prevalence of dysphonia, as part of the COVID-19 symptoms, was assessed. The outcomes were compared between dysphonic and nondysphonic patients. The association between dysphonia severity and outcomes was studied through Bayesian analysis.
RESULTS: A total of 188 patients were dysphonic, accounting for 26.8% of cases. Females developed more frequently dysphonia than males (P = 0.022). The proportion of smokers was significantly higher in the dysphonic group (P = 0.042). The prevalence of the following symptoms was higher in dysphonic patients compared with nondysphonic patients: cough, chest pain, sticky sputum, arthralgia, diarrhea, headache, fatigue, nausea, and vomiting. The severity of dyspnea, dysphagia, ear pain, face pain, throat pain, and nasal obstruction was higher in dysphonic group compared with nondysphonic group. There were significant associations between the severity of dysphonia, dysphagia, and cough.
CONCLUSION: Dysphonia may be encountered in a quarter of patients with mild-to-moderate COVID-19 and should be considered as a symptom list of the infection. Dysphonic COVID-19 patients are more symptomatic than nondysphonic individuals. Future studies are needed to investigate the relevance of dysphonia in the COVID-19 clinical presentation.