Journal of perinatology : official journal of the California Perinatal Association · 2018
Outcomes of early inhaled nitric oxide use in premature African American neonates.
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Collura Christopher A, Mara Kristin C, Weaver Amy L, Clark Reese H, Carey William A
Аннотация
OBJECTIVE: Meta-analysis of individual-patient clinical trial data suggests that inhaled nitric oxide (iNO) improves respiratory outcomes in premature African American neonates. We hypothesized that early iNO therapy would be associated with lower mortality and less chronic lung disease (CLD) in extremely premature African American neonates.
STUDY DESIGN: We conducted a retrospective cohort study of propensity score- and race-matched neonates 22-29 weeks gestation who were mechanically ventilated for treatment of respiratory distress and associated pulmonary hypertension (RDS + PPHN). We evaluated the association of iNO within 7 days of life with in-hospital mortality and CLD, using Cox proportional hazards regression and logistic regression, respectively.
RESULT: Among 178 matched pairs of African American patients, iNO was not associated with lower mortality (HR = 0.94, 95% CI 0.69-1.30) or less CLD (OR = 0.94, 95% CI 0.47-1.87).
CONCLUSIONS: Early, off-label iNO use is not associated with improved outcomes in premature African American neonates with RDS + PPHN.
STUDY DESIGN: We conducted a retrospective cohort study of propensity score- and race-matched neonates 22-29 weeks gestation who were mechanically ventilated for treatment of respiratory distress and associated pulmonary hypertension (RDS + PPHN). We evaluated the association of iNO within 7 days of life with in-hospital mortality and CLD, using Cox proportional hazards regression and logistic regression, respectively.
RESULT: Among 178 matched pairs of African American patients, iNO was not associated with lower mortality (HR = 0.94, 95% CI 0.69-1.30) or less CLD (OR = 0.94, 95% CI 0.47-1.87).
CONCLUSIONS: Early, off-label iNO use is not associated with improved outcomes in premature African American neonates with RDS + PPHN.
Предметные рубрики MeSH
Administration, InhalationBlack or African AmericanFemaleGestational AgeHospital MortalityHumansHypertension, PulmonaryInfant, Extremely PrematureInfant, NewbornInfant, Premature, DiseasesLogistic ModelsMaleNitric OxidePropensity ScoreProportional Hazards ModelsRespiratory Distress Syndrome, NewbornRetrospective Studies