Медицинская библиотека · Zhonghua nan ke xue = National journal of andrology · 2002

[The changes of IL-1 and NO levels in the testes of rats with experimental varicocele].

Chen Li-Ping, Wang Shu-Qiu, Zhao Yu-Zhen, Liu Lei, Wang Shu-Xiang, Lu Ya-Zhen

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Аннотация

OBJECTIVES

To evaluate the effects of varicocele (VC) on IL-1 and NO levels in testes of rats with VC.

METHODS

Male adult Wistar rats were divided into two groups randomly, VC group (n = 30) and pseudo-operation group (n = 20), and the levels of IL-1 and NO in the testes were determined and compared.

RESULTS

The levels of IL-1 and No of left tests in VC group were higher than those in pseudo-operation group, respectively(P < 0.01). While the levels of IL-1 and NO of right testes between two groups were not significantly different (P > 0.05). More over, the level of IL-1 correlated significantly with that of NO(r = 0.572, P < 0.01).

CONCLUSIONS

The results revealed that the changes of IL-1 and NO levels in the testes of rats with VC might be the reason which caused testes damage, disturbance of spermatogenesis and even infertility.

Для цитирования: Chen Li-Ping, Wang Shu-Qiu, Zhao Yu-Zhen, Liu Lei, Wang Shu-Xiang, Lu Ya-Zhen. [The changes of IL-1 and NO levels in the testes of rats with experimental varicocele].. Zhonghua nan ke xue = National journal of andrology. 2002.

Предметные рубрики MeSH

Animals Disease Models, Animal Interleukin-1 Male Nitric Oxide Rats Rats, Wistar Testis Varicocele

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