Obesity surgery · 2026
The Effect of Acute Aerobic Exercise On the Time Spent in Hypoglycaemia After Bariatric Surgery (The BariEX Study).
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Podesta-Donoso Israel, Papamargaritis Dimitris, Henson Joe, Katsarova-Harrison Stanislava, Tziannou Aikaterina, Waller Helen, Rowlands Alex V, Bowrey David, Anyiam Oluwaseun, Idris Iskandar, Stensel David J, Webb David R, Zalin Anjali, Yates Tom, Choudhary Pratik, Davies Melanie J, Herring Louisa Y
Аннотация
OBJECTIVE: To determine whether a pre-lunch single bout of moderate-intensity aerobic exercise (AEX) alters time spent in hypoglycaemia (<3.0 mmol/L) during the subsequent 24 hours (24-h) and parameters of glucose homeostasis in individuals without diabetes after metabolic/bariatric surgery (MBS).
METHODS: In a randomised crossover study, 15 participants completed two conditions: 30min treadmill walking at 60% V̇O₂peak (AEX) and time-matched sitting (CON). After an overnight fast and a standardised breakfast, participants performed AEX or CON, and both conditions were followed by an identical lunch administered as a mixed-meal tolerance test (MMTT). Continuous glucose monitoring (CGM) assessed glucose levels for 24-h post-intervention, during which participants consumed standardised meals. CGM data were available for analysis in 11 participants. The primary outcome was time spent with glucose <3.0 mmol/L during the 24-h post-intervention. Secondary outcomes included other CGM-derived glucose metrics and plasma glucose and insulin responses during the 3-h MMTT.
RESULTS: Only one isolated hypoglycaemic event (<3.0 mmol/L) occurred, precluding statistical analysis of the primary outcome. Mean 24-h glucose (AEX: 6.4 (1.0); CON: 6.5 (0.9) mmol/L; p = 0.57) and time <3.9 mmol/L (AEX 0 (0.0, 0.5); CON 0 (0.0, 0.5) %; p = 0.68) did not differ between conditions. AEX reduced glucose coefficient of variation (p < 0.01). During the MMTT, nadir, peak, and AUC0-180 glucose, as well as pre-MMTT insulin concentrations, were higher following AEX (all p < 0.05).
CONCLUSIONS: A pre-lunch 30-min bout of AEX did not increase the 24-h risk of hypoglycaemia post-MBS but elevated post-MMTT glucose levels.
METHODS: In a randomised crossover study, 15 participants completed two conditions: 30min treadmill walking at 60% V̇O₂peak (AEX) and time-matched sitting (CON). After an overnight fast and a standardised breakfast, participants performed AEX or CON, and both conditions were followed by an identical lunch administered as a mixed-meal tolerance test (MMTT). Continuous glucose monitoring (CGM) assessed glucose levels for 24-h post-intervention, during which participants consumed standardised meals. CGM data were available for analysis in 11 participants. The primary outcome was time spent with glucose <3.0 mmol/L during the 24-h post-intervention. Secondary outcomes included other CGM-derived glucose metrics and plasma glucose and insulin responses during the 3-h MMTT.
RESULTS: Only one isolated hypoglycaemic event (<3.0 mmol/L) occurred, precluding statistical analysis of the primary outcome. Mean 24-h glucose (AEX: 6.4 (1.0); CON: 6.5 (0.9) mmol/L; p = 0.57) and time <3.9 mmol/L (AEX 0 (0.0, 0.5); CON 0 (0.0, 0.5) %; p = 0.68) did not differ between conditions. AEX reduced glucose coefficient of variation (p < 0.01). During the MMTT, nadir, peak, and AUC0-180 glucose, as well as pre-MMTT insulin concentrations, were higher following AEX (all p < 0.05).
CONCLUSIONS: A pre-lunch 30-min bout of AEX did not increase the 24-h risk of hypoglycaemia post-MBS but elevated post-MMTT glucose levels.