Complications of advanced prostate cancer.

Currently, there is a lot of focus directed toward discovering treatments for patients with hormone refractory prostate cancer (HRPC) that will lead to increased survival. Until such treatments emerge, palliation is important to ensure patients the highest possible quality of life. Most disabling among symptoms associated with disease progression are bone pain, bone fracture, urinary tract obstruction, spinal cord compression, coagulation disorders, anemia, and edema. Diverse treatments, such as radiation therapy, surgery, chemotherapy, and supportive measures, can improve the impact of these problems, although improved symptom control is needed in some areas.