Arquivos brasileiros de endocrinologia e metabologia · 2011
TSH neurosecretory dysfunction (TSH-nd) in Down syndrome (DS): low risk of progression to Hashimoto's thyroiditis.
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Faria Claudia Dutra Costantin, Ribeiro Simone, Kochi Cristiane, Silva Aryane Pereira Neves da, Ribeiro Bruna Natalia Freire, Marçal Lilian Teixeira, Santos Felipe Henrique Yyazawa, Eduardo Calliari Procópio Luis, Monte Osmar, Longui Carlos Alberto
Аннотация
INTRODUCTION: Patients with Down syndrome (DS) often have elevated TSH (hypothalamic origin), which is called TSH neurosecretory dysfunction (TSH-nd). In these cases, there is slight elevation in TSH (5-15 µUI/mL), with normal free T4 and negative thyroid antibodies (AB).
OBJECTIVE: To recognize the risk of progression to Hashimoto's thyroiditis (HT).
SUBJECTS AND METHODS: We retrospectively analyzed 40 DS patients (mean age = 4.5 years), followed up for 6.8 years.
RESULTS: HT was diagnosed in 9/40 patients, three early in monitoring, and six during evolution. In 31/40 patients, TSH-nd diagnosis remained unchanged over the years, with maximum TSH values ranging from 5 to 15 µUI/mL. In this group, free T4 also remained normal and AB were negative. There was a significant TSH reduction (p = 0.017), and normal TSH concentrations (< 5.0 µUI/mL) were observed in 29/31 patients, in at least one moment. No patient had TSH > 15 µUI/mL.
CONCLUSION: DS patients with TSH-nd present low risk of progression to HT (10% for females and 6% for males).
OBJECTIVE: To recognize the risk of progression to Hashimoto's thyroiditis (HT).
SUBJECTS AND METHODS: We retrospectively analyzed 40 DS patients (mean age = 4.5 years), followed up for 6.8 years.
RESULTS: HT was diagnosed in 9/40 patients, three early in monitoring, and six during evolution. In 31/40 patients, TSH-nd diagnosis remained unchanged over the years, with maximum TSH values ranging from 5 to 15 µUI/mL. In this group, free T4 also remained normal and AB were negative. There was a significant TSH reduction (p = 0.017), and normal TSH concentrations (< 5.0 µUI/mL) were observed in 29/31 patients, in at least one moment. No patient had TSH > 15 µUI/mL.
CONCLUSION: DS patients with TSH-nd present low risk of progression to HT (10% for females and 6% for males).