Frontiers in medicine · 2025
Post-infectious cough in patients with obesity: an observational study.
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Xian Yin, Zhang Yuan, Kong Xiangxin, Song Ke
Аннотация
BACKGROUND: Upper respiratory tract infection (URTI) can lead to post-infectious cough (PIC). It is currently unclear the current status and influencing factors of PIC in patients with obesity.
METHODS: Data were collected from patients who visited the institution's bariatric surgery clinic, between June and November 2022, but did not undergo surgery. Follow-up calls will be conducted in early January 2023, and whether these patients develop URTI and cough in December 2022 will be recorded. For patients with URTI and cough, the occurrence of accompanying symptoms during the course of the disease will be recorded. Then, in late February 2023, we will assess whether the cough or other accompanying symptoms have completely resolved within 8 weeks. Logistic regression analyzed the influencing factors of URTI developing into PIC in obese patients. Subgroup analyzes were used to assess interaction effects.
RESULTS: Out of 286 study participants, 54 (18.9%) had a PIC. Waist circumference (WC) [odds ratio (OR) 1.07, 95% confidence interval (CI): 1.03-1.12], homeostasis model assessment for insulin resistance (OR 1.51, 95% CI: 1.15-1.98), and vomiting during the acute phase (OR 3.42, 95% CI: 1.39-8.4) were associated with PIC in patients with obesity. Vomiting during the acute phase (p for interaction = 0.033) can affect the risk of WC to PIC.
CONCLUSION: WC, insulin resistance, and vomiting during the acute phase are risk factors for PIC in patients with obesity. Reducing visceral fat and increasing insulin sensitivity in obese patients may help alleviate the burden of PIC.
METHODS: Data were collected from patients who visited the institution's bariatric surgery clinic, between June and November 2022, but did not undergo surgery. Follow-up calls will be conducted in early January 2023, and whether these patients develop URTI and cough in December 2022 will be recorded. For patients with URTI and cough, the occurrence of accompanying symptoms during the course of the disease will be recorded. Then, in late February 2023, we will assess whether the cough or other accompanying symptoms have completely resolved within 8 weeks. Logistic regression analyzed the influencing factors of URTI developing into PIC in obese patients. Subgroup analyzes were used to assess interaction effects.
RESULTS: Out of 286 study participants, 54 (18.9%) had a PIC. Waist circumference (WC) [odds ratio (OR) 1.07, 95% confidence interval (CI): 1.03-1.12], homeostasis model assessment for insulin resistance (OR 1.51, 95% CI: 1.15-1.98), and vomiting during the acute phase (OR 3.42, 95% CI: 1.39-8.4) were associated with PIC in patients with obesity. Vomiting during the acute phase (p for interaction = 0.033) can affect the risk of WC to PIC.
CONCLUSION: WC, insulin resistance, and vomiting during the acute phase are risk factors for PIC in patients with obesity. Reducing visceral fat and increasing insulin sensitivity in obese patients may help alleviate the burden of PIC.