Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2025
Prevalence and Predictors of Non-adherence to Oral Anticoagulation Therapy Up To 24 Months After Acute Pulmonary Embolism: Results from a Prospective Observational Study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Mayr Wolfgang, Kempkens Lana, Härtl Christoph, Haberl Sabine, Linseisen Jakob, Kirchberger Inge, Meisinger Christa, Berghaus Thomas M
Аннотация
BackgroundOral anticoagulation (OAC) therapy is essential to avoid venous thromboembolism recurrence, but drug-adherence sometimes might be poor.AimTo describe OAC adherence in patients after acute pulmonary embolism (PE) and to identify risk factors for non-adherence.MethodsWe prospectively evaluated 324 PE patients (mean age 62.9 ± 14.3, 51.5% male) after 3, 6, 12 and 24 months, resulting in 1620 study visits. Data were analyzed using multivariable logistic models.ResultsOut of the study population, 19 patients (5.9%) were identified to be non-adherent to OAC therapy. Significant predictors of non-adherence were a history of stroke and diabetes mellitus (DM) (OR = 6.07, 95% CI 1.58-23.36, P = .027 and OR = 3.46, 95% CI 1.15-10.40, P = .009, respectively).ConclusionThe adherence rate to OAC is quite high in patients after acute PE, but patients with DM and a history of stroke should be focused on in order to further improve OAC adherence.