Movement disorders : official journal of the Movement Disorder Society · 2006
Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Matsui Hideaki, Nishinaka Kazuto, Oda Masaya, Hara Narihiro, Komatsu Kenichi, Kubori Tamotsu, Udaka Fukashi
Аннотация
Little is known about the developing mechanisms of visual hallucinations in Parkinson's disease. This study aimed to investigate perfusion changes in parkinsonian patients with visual hallucinations using n-isopropyl-p-[123I]iodoamphetamine ([123I]IMP) single photon emission computed tomography imaging. A total of 70 consecutive patients, including 31 patients with visual hallucinations, and 39 patients without hallucinations, participated in this study. Patients with severe cognitive impairment (Mini-Mental State Examination score < 20), nonvisual hallucinations, or confusion were excluded. We compared brain perfusion changes between the two groups. We found that hallucinatory patients had significant perfusion reductions in the bilateral inferior parietal lobule, inferior temporal gyrus, precuneus gyrus, and occipital cortex compared to nonhallucinatory patients. These results suggested that hypoperfusion of the visual pathway was closely related to visual hallucinations in Parkinson's disease.