Lung · 2025
Airway Mucus Plugs in Patients with Chronic Cough: A Single-Center Observational Study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Beck Kyongmin Sarah, Han Dae Hee, Jeon Hyun-Seob, Shin Juyoung, Lee Sook Young, Song Woo-Jung, Lee Hwa Young
Аннотация
BACKGROUND: This study investigated the prevalence of mucus plugs and their clinical associations in patients with chronic cough.
METHODS: Chest computed tomography (CT) scans were evaluated in patients with chronic cough and healthy controls.
RESULTS: Among 82 patients with chronic cough and 71 controls, mucus plugs were identified in 31.7% and 5.6%, respectively. Higher mucus plug scores were associated with older age, elevated fractional exhaled nitric oxide (FeNO), and lower total Cough Hypersensitivity Questionnaire (CHQ) scores (all P < 0.05). Regression analysis revealed associations with higher FeNO and lower total CHQ scores (Model 1: R2 = 0.396, P < 0.001), and with higher immunoglobulin (Ig) E levels (Model 2: R2 = 0.388, P < 0.001). Mucus plug scores did not differ by 1-month treatment response.
CONCLUSIONS: Mucus plugs were prevalent in chronic cough and associated with type 2 airway inflammation. Their clinical significance warrants further investigation.
METHODS: Chest computed tomography (CT) scans were evaluated in patients with chronic cough and healthy controls.
RESULTS: Among 82 patients with chronic cough and 71 controls, mucus plugs were identified in 31.7% and 5.6%, respectively. Higher mucus plug scores were associated with older age, elevated fractional exhaled nitric oxide (FeNO), and lower total Cough Hypersensitivity Questionnaire (CHQ) scores (all P < 0.05). Regression analysis revealed associations with higher FeNO and lower total CHQ scores (Model 1: R2 = 0.396, P < 0.001), and with higher immunoglobulin (Ig) E levels (Model 2: R2 = 0.388, P < 0.001). Mucus plug scores did not differ by 1-month treatment response.
CONCLUSIONS: Mucus plugs were prevalent in chronic cough and associated with type 2 airway inflammation. Their clinical significance warrants further investigation.